姓 名:陈发杰 性 别:男 职 称:副教授/硕士生导师 学 历:博士 职 务: 电 话:18868818089 专 业:有机化学 电子邮件:fajie.chen@fzu.edu.cn 研究方向:有机合成方法学,多肽化学 课题组主页:https://www.x-mol.com/groups/fajie_chen |
教育与工作经历
2023.02至今 澳门永利唯一官方网址,副教授
2020.11-2022.11 波士顿学院 (Boston College), 美国,博士后,导师: Jianmin Gao教授
2018.11-2020.11 伊利诺伊大学芝加哥分校 (University of Illinois at Chicago), 美国,博士后,导师: Daesung Lee教授
2016.10-2018.11 中国科学院福建物质结构研究所,博士后,苏伟平 教授
2011.9-2016.9 浙江大学化学系,博士,导师:史炳锋 教授,吴军教授
2007.9-2011.6 学院化学化工学院,本科,导师:陈义平 教授,史炳锋 教授
教学简介
科研简介
主要从事有机合成方法学、多肽化学等研究,已在Angew. Chem. Int. Ed. 、Chem. Sci.、Org. Lett.、Org. Chem. Front.等国际刊物上发表SCI论文14篇,其中2篇论文入选ESI高被引论文,1篇热点论文,论文总被引用1000余次。研究成果先后多次被 ChemInform, Synfacts, Chin. J. Org. Chem.等作为亮点进行报道。主持国家自然科学基金1项,参与国家自然科学基金2项。
科研领域主要涉及:
1. 复杂环肽的合成
2. 天然多肽的特异性修饰与转化
3. 惰性化学键的活化与转化
社会兼职
科研项目
4. 天然多肽的特异性修饰与拓扑结构调控研究(511264),学院“旗山学者”海外项目,2023-2027,在研,主持
3. 过渡金属催化的饱和羰基化合物的脱氢/双官能团化串联反应研究(21702205),国家自然科学基金青年项目, 2018-2020,已结题,主持
2. β-取代色氨酸合成方法及其在Maremycins和TMC-95A的合成应用研究(21402170),国家自然科学基金青年项目, 2015-2017,已结题,参与
1. 新型糖肽类抗生素Mannopeptimycins的仿生合成及多样化合成(21272206),国家自然科学基金面上项目,2013-2016,已结题,参与
代表性论文
14. Chen, Fa-Jie;# Pinnette, Nicole;# Yang, Fan; Gao, Jianmin.* "A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization" Angew. Chem. Int. Ed. 2023, e202306813.
13. Chen, Fa-Jie; Gao, Jianmin.* "Fast Cysteine Bioconjugation Chemistry" Chem. Eur. J. 2022, e202201843. (Invited Review)
12. Zheng, Mengmeng; Chen, Fa-Jie, Li, Kaicheng; Reja, Rahi M.; Haeffner, Fredrik; Gao, Jianmin* "Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display" J. Am. Chem. Soc. 2022, 144, 15885-15893.
11. Chen, Fa-Jie;# Zheng, Mengmeng,# Nobile, Vincent, Gao, Jianmin.* "Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes" Chem. Eur. J. 2022, e202200058. (Hot paper)
10. Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkatareddy; Liu, Huaqing; Lee, Daesung* Xia, Yuanzhi*. "Three-component Coupling Reaction for the Synthesis of Fully Substituted Triazoles: Reactivity Control of Cu-Acetylide toward Alkyl Azides and Diazo Compounds" Org. Chem. Front., 2021, 8, 6095.
9. Chen, Fa-Jie; Hua, Zhenguo; Chen, Jianhui; Chen, Jiajia; Lee, Daesung* and Xia, Yuanzhi*. "One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation" Front. Chem. 2020, 8, 621545.
8. Chen, Fa-Jie; Lin, Yongjia; Xu, Man; Xia, Yuanzhi*; Wink, Donald J.; Lee, Daesung*. "C–H Insertion by Alkylidene Carbenes to Form 1,2,3-Triazines and Anionic [3 + 2] Dipolar Cycloadditions To Form Tetrazoles: Crucial Roles of Stereoelectronic and Steric Effects" Org. Lett. 2020, 22, 2, 718-723.
7. Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping.* "Copper-catalyzed Dehydrogenative γ-C(sp3)-H Amination of Saturated Ketones for Synthesis of Polysubstituted Anilines" Nat. Comm. 2019, 10, 3681.
6. Zhao, Sheng; Chen, Fa-Jie; Liu, Bin; Shi, Bing-Feng.* "Copper-Catalyzed Direct Acyloxylation of C(sp2)-H Bonds with Benzoic Acids" SCIENCE CHINA Chemistry, 2015, 58, 1302-1309.
5. Zhao, Sheng; Liu, Yue-Jin; Yan, Sheng-Yi; Chen, Fa-Jie; Zhang, Zhuo-Zhuo; Shi, Bing-Feng.* "Copper-/Silver-Mediated Arylation of C(sp2)–H Bonds with 2-Thiophenecarboxylic Acids." Org. Lett. 2015, 17, 3338-3341.
4. Chen, Fa-Jie; Liao, Gang; Li, Xin; Wu, Jun*; Shi, Bing-Feng* "Copper-Mediated C–S/N–S Bond Formation via C–H Activation: Access to Benzoisothiazolones Using Elemental Sulfur" Org. Lett. 2014, 6, 5644-5647.
3. Li, Xin; Liu, Yan-Hua; Gu, Wen-Jia; Li, Bo; Chen, Fa-Jie; Shi, Bing-Feng.* "Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary" Org. Lett. 2014, 16, 3904-3907.
2. Zhang, Qi; Chen, Kai; Rao, Wei-Hao.; Zhang, Yuejun; Chen, Fa-Jie, Shi, Bing-Feng.* "Stereoselective Synthesis of Chiral α-Amino-β-Lactams via Pd(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)–H Bonds" Angew. Chem. Int. Ed. 2013, 52, 13588-13592. (高被引论文)
1. Chen, Fa-Jie; Zhao, Sheng; Hu, Fang; Chen, Kai; Zhang, Qi; Zhang, Shuo-Qing; Shi, Bing-Feng.* "Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers" Chem. Sci. 2013, 4, 4187-4192. (Top 25 most-read Chemical Science articles in 2013) (高被引论文)
获奖情况
2023年入选学院“旗山学者”(海外项目)
2018年入选中国科学院福建物质结构研究所“精英博士后”
2015年入选浙江大学“优秀研究生”
其他